Block-US
Block-US is an Inno-Sol patented solution addressing side-leakage and mode conversion of
ultrasound waves in commercial well plates. It uses a proprietary polymer to fill inter-well spaces,
compatible with all disposable cell culture plates. The polymer absorbs transverse waves and
dampens lateral diffusion when plates are sonicated from the bottom. Ultrasound interacting with
the bottom lamina can generate mode conversion, affecting waves within the material and the
solution. Block-US effectively reduces these surface and internal wave effects, improving
experimental consistency.
Benefits
The use of Block-US enables accurate quantitative assessment of the acoustic field in the target well by minimizing transverse wave propagation and interfering phenomena in adjacent wells. This allows all wells in a plate to be sonicated simultaneously without interference, saving time and reducing the number of plates needed. Previously, researchers avoided sonicating neighboring wells to limit these effects, significantly reducing the number of wells usable in each experiment.
Targeted usage:
To be used by all Researchers dealing with cell-ultrasound stimulation under controlled conditions.
Compatible with any brand and format of plate (Falcon, Eppendorf, Corning, Greiner, Nunc, etc), and number of wells ( 6 up to 96 wells ). The multiwell plates are supplied by the customer, at the Inno-sol facility filled with polymer and then sterilized using UV light ( service model ).
Experimental proof:
When sonicating > 1MPa in the target well, dampens down to > 3-fold the conversion of wave modes propagation to nearby wells compared to control with no-polymer, air or water filling.
Work in progress with different Research Centers
Packaging:
It is saleable in single unit, or five-unit packages and UV-sterilized (several options are available for this product, please ask details). For technical information and quotations, please contact us to amministrazione@inno-sol.it
